PARIS & BOULDER, Colo.–(BUSINESS WIRE)–Regulatory News:
SpineGuard (FR0011464452 – ALSGD, PEA-PME eligible) (Paris:ALSGD), an innovative company that deploys its digital technology for real-time surgical guidance (DSG) to secure and simplify the placement of bone implants, announces the start of a new 3-year collaborative program with two laboratories from Sorbonne University, CNRS and Inserm: ISIR (Institute of Intelligent Systems and Robotics) and LIB (Biomedical Imaging Laboratory).
DSG technology is based on the measurement of local electrical conductivity of tissues in real time and without X-rays, with a sensor placed at the tip of the drilling tool. Its effectiveness is proven by more than 90,000 surgeries worldwide and 19 scientific publications. Since 2017, SpineGuard has been collaborating with ISIR to apply DSG to surgical robots to improve their safety, accuracy and autonomy.
SpineGuard and ISIR are capitalizing on the world-class results already published…
After a first phase of collaboration, SpineGuard announced experimental results of sub-millimeter precision in the detection of the bone border and the automatic stopping of vertebral drilling carried out by a robot using DSG technology. These impressive results were presented during their development successively at the Hamlyn Symposium on Medical Robotics in London in May 2019, winning the prize for the best scientific article, then in plenary session at the International Congress of Minimally Invasive Spinal Surgery (SMISS) in Las Vegas in November 2021, and finally, at the CRAS conference in Naples in April 2022.
…and join forces with the LIB laboratory to add ultrasound to the project
On the strength of these successes, the research and development teams want to go even further in the advancement of surgical robots: the guidance technologies that allow the robot to position itself correctly in relation to the patient to find the entry point for the drilling are based currently on the use of health-hazardous X-ray imaging in combination with cumbersome optical tracking. However, SpineGuard has been exploring for a long time the possibility of using ultrasound in addition to DSG for this preliminary step, before the tool penetrates the bone, and has obtained the validation of two families of international patents on this subject. The LIB laboratory, which has world-class expertise in the field of ultrasound imaging, responded enthusiastically to the invitation to join the project. SpineGuard, ISIR and LIB are thus starting a new 3-year collaboration whose production of disruptive results in the field is expected.
Stéphane Bette, co-founder and Deputy CEO of SpineGuard says: ” We are very happy to launch this partnership which will allow us to go even further in improving surgical robots in orthopedics. This new phase of research aims to enable robots to autonomously and safely perform drilling and bone cutting, as well as the insertion of implants into the human skeleton. Our objective is to implement a collaboration of excellence between French industry and research, to lead to an exploitation in the field of orthopedics via strategic agreements with the actors of the sector. »
Guillaume Morel and Brahim Tamadazte, respectively University Professor at Sorbonne University and Director of ISIR, and Research Fellow at CNRS and member of ISIR add: “We are delighted to continue a very close and dynamic collaboration with SpineGuard since 2017. The entry of robotics and associated new technologies into operating theaters is undoubtedly among the greatest medical advances of the past twenty years. Robotic approaches often make the surgical gesture less invasive, more precise, safer and more intuitive for many surgical procedures. The first results from previous collaborations allow us to have better visibility on the clinical added value that a robot equipped with original and efficient sensors can bring to orthopedic surgery in general, and spinal surgery in particular. In this new collaboration, it will be a question in particular of the development of ultrasonic sensors which will be coupled with robotic approaches. This original and promising association will allow the surgeon to define with precision and non-invasively the entry point and the trajectory of the pedicle screws in the spine without using ionizing and/or costly preoperative imaging (scanner or MRI). ). The association of two prestigious laboratories of Sorbonne University (ISIR and LIB), whose skills are very complementary with the industrial vision of SpineGuard, constitutes a stimulating work environment conducive to innovation. The adventure with SpineGuard will thus continue for the next three years, with the focus on several technological and scientific innovations expected to serve the patient and the medical profession. »
Quentin Grimal, Professor at Sorbonne University and Head of the “Ultrasound and imaging for the characterization of bone quality” team at LIBconcludes: “Using ultrasound to position a surgical tool is particularly relevant. Ultrasounds are harmless and provide real-time information on the position of the interfaces, the bone anatomy, and even the mechanical quality of the bone. The use of an ultrasound probe should make it possible to optimally position the robotic arm at the entry point of the drilling for the placement of the pedicle screws in the spine. In general, ultrasound cannot see beyond bone surfaces because ultrasound is strongly reflected off the surface of bone and very attenuated as it propagates through bone. However, the low amplitude ultrasound signals coming from inside the bones can be exploited by implementing specific treatments which are a specialty of our team. “Ultrasound and imaging for the characterization of bone quality”. This team, a pioneer in the use of ultrasound to probe bone, has introduced several approaches that offer an alternative to X-rays for characterizing cortical or trabecular bone health. For our team, this partnership with SpineGuard and ISIR is particularly timely: it will accelerate methodological and instrumental developments that will allow wider use of ultrasound in orthopedic surgery. We are very happy to participate in this innovative project for ultrasonic methods and instrumentation. »
Founded in 2009 by Pierre Jérôme and Stéphane Bette, based in Paris and Boulder in the United States, SpineGuard is an innovative company that deploys its DSG® digital technology for real-time surgical guidance without X-rays to secure and simplify the placement of bone implants. The company designs, develops and markets worldwide innovative medical devices used in more than 90,000 surgeries to date. Numerous scientific studies, including 19 published in leading medical journals, have established the reliability and precision of DSG® technology and its many benefits for patients, surgeons, hospital staff and healthcare systems. Building on these fundamentals and strategic partnerships, SpineGuard is extending the applications of its DSG® technology to innovations such as the “intelligent” pedicle screw, the DSG Connect visualization and recording interface, surgical robotics and dental implantology. . DSG® was invented by Maurice Bourlion, Dr Ciaran Bolger and Alain Vanquaethem, the company has been labeled an “innovative company” by Bpifrance since 2009 and is committed to a CSR approach.
More information at www.spineguard.com
ISIR is one of the largest French research establishments in robotics and intelligent systems whose main guardianship is Sorbonne University, the CNRS (National Center for Scientific Research) and Inserm (National Institute for Health and Medical Research). It brings together more than 50 teacher-researchers and permanent researchers and around 80 doctoral and post-doctoral students. ISIR is organized around six research teams devoted to artificial intelligence and machine learning, mobile robotics, small-scale robotics, assistance robotics (rehabilitation and motor skills assistance), to the interaction between man and a robot and also to the robotics of assistance to the surgical gesture. ISIR has extensive experience in the design of innovative robotic architectures, their modeling and control, in clinical validation and the transfer of results with high industrial potential. Over the past 5 years, 10 preclinical or clinical studies have been carried out at ISIR. 8 patents were granted and 2 start-ups were launched.
The Biomedical Imaging Laboratory (LIB) specializes in fundamental and applied research into morphological, functional and molecular biomedical imaging methods on small animals and humans. Its supervisory bodies are: Sorbonne University, CNRS and Inserm. It brings together 35 permanent researchers and teacher-researchers (about half of whom are also hospital practitioners), about 10 engineers and technicians and more than 30 doctoral and post-doctoral students. The LIB is organized into six teams whose research themes target the main public health priorities of the 21st century.th century: cancer, cardiovascular and neurological diseases, bone quality. The LIB develops new diagnostic and treatment methodologies using many modalities: ultrasound, MRI, CT, SPECT-PET, etc. LIB has a strong commitment to technology transfer. Over the past 5 years, 6 patents have been granted, 7 software applications have been filed and 5 start-ups have been launched.
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