The National Agency for the Safety of Medicines evokes this Friday, April 15, cases of vasculitis after vaccination with the Moderna vaccine (Spikevax). Vaccine-related adverse effects that require special expertise. A potential signal to study considers the ANSM.
A new report published this Friday, April 15 by the ANSM (the National Agency for the Safety of Medicines) reports several case of adverse effects observed in data from March 25 to April 7, 2022. According to the agency, since the start of vaccination with the Spikevax vaccine (Modern) 25,314 cases of adverse effects were analysed, of which “a large number of cases concern non-serious local delayed reactions” it is specified.
But, following “an analysis of the cases of vasculitis“, the monitoring committee considers that this may be “a potential signal with the Spikevax vaccine” which should lead to a “skill particular“.
While the number of reported cases, 26 proven out of the 62 analyzed, compared to the number of people vaccinated with Moderna is very low, this new study analyzes several autoimmune and inflammatory pathologies identified after an injection of the vaccine. But what are we talking about?
“Vasculitides are a group of conditions having in common a inflammatory damage leading to a fibrosis of the walls of arterial, venous and capillary vessels. The symptomatology depends on the type and number of affected vessels”, indicates the ANSM.
The suffix “itis” indeed suggests cases of vascular inflammation, that is to say blood vessels. This inflammation can thus damage the tissues and organs directly supplied by these vessels. In total, it is estimated that there are about fifteen pathologies, quite rare, linked to vasculitis. They can affect both women and men of all ages. . The average time to onset is 9.3 days after vaccination.
Links to Kawasaki disease
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“Vasculitides are recognized complications of SARS CoV2 disease (which include complications of the type Kawasaki reported especially in children). They would be linked to the inflammatory and immune response of the disease, relative severity since intensive care is necessary for a third of patientsand the mortality is 16% according to a summary study of the complications of SARS CoV2”, can we read.
“Apart from Kawasaki, vasculitis of large and small vessels as well as cutaneous vasculitis are described, appearing within 2 weeks following Covid disease and can be serious, involving several organs”, further specifies the document.
In view of this study, the ANSM considers as serious the threat of vasculitis after an injection of Moderna vaccine: “Special vigilance must be exercised in patients who present, soon after vaccination and once the context of reactogenicity has been ruled out, non-specific symptoms which persist in an inflammatory context”, estimates the agency, which announces that it will continue the observations because it is a question there, “in particular of damage to small vessels”, of a “potential signal”.
In total, since the start of vaccination with Moderna, more than 23,571,000 injections have been performed as of April 7, 2022.