Covid-19: the effectiveness of vitamin D demonstrated on elderly patients

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A study conducted by the CHU of Angers confirms the usefulness of vitamin D in the treatment of Covid-19. This reduces the death rate in elderly patients at risk.

A study led by the CHU of Angers and labeled by the State demonstrates “with a very high level of evidence” the interest of the use of vitamin D in the treatment against Covid-19, reports Pr Cédric Annweiler , head of the geriatrics department of the CHU to our colleagues from West France. Called COVIT-TRIAL and published this Tuesday, May 31 in the scientific journal Plos Medicine, this study presents an “important and coherent” result according to the researcher.

“The anti-inflammatory effects of vitamin D very significantly reduce the risk of death at 14 days, clearly avoiding the inflammatory runaway and cytokine storm observed in severe forms of Covid-19”, observes Cédric Annweiler.

Well known for its calcium-binding effects on the bones, vitamin D is frequently prescribed to children throughout their growth and to the elderly to prevent osteopenia. It also has anti-inflammatory properties to fight against infectious and cancerous diseases.

“Significant reduction in the risk of death”

To achieve these results, the researchers solicited 260 patients, “distributed in nine French hospitals and their Ehpads”. These were “patients aged 65 and over, suffering from Covid-19 with unfavorable evolution criteria”, and “patients aged 75 and over suffering from Covid-19 without any other risk factor”, specifies Cedric Annweiler. They were randomly divided into two groups. The researchers administered to the first “a high dose of vitamin D within 72 hours of their diagnosis”, and to the second “a much lower dose, always within the same period of time”, according to the professor.

Conclusion: “the administration of the high dose of vitamin D […] was at the origin of a significant and statistically significant reduction in the risk of death, and this from the sixth day after the start of treatment”, notes Cédric Annweiler. His team therefore recommends reaching “as quickly as possible a status satisfactory in vitamin D in the elderly with Covid-19, using high-dose supplementation as soon as the diagnosis is made.

Last January, 73 French-speaking experts and six national learned societies gathered around Pr Cédric Annweiler and Pr Jean-Claude Souberbielle of the Necker hospital in Paris insisted on the effectiveness of vitamin D against Covid-19.

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